Copper Peptide Direct

Compounded, not FDA-approved

GHK-Cu is one molecule sold as three products, and only the paperwork tells them apart

A cosmetic serum the law never reviews, a compounded cream living inside an interim FDA policy whose dates changed twice in two weeks of 2026, and an injectable vial FDA has flagged for impurity risk. The molecule is the same; the evidence is not. Our study table grades every row by species, route, tier and the compound actually tested: the strongest human result is an industry-run wound trial from 1994, the only RCT-tagged study of GHK-Cu products was objective-null, and the injectable tier has zero human studies of any kind.

  • 27graded rows in our study table, each with species, route, tier and compound tested
  • 5of them human evidence, and the table says exactly which kind
  • 0human studies of injected GHK-Cu, a zero the vial market never prints
  • 53fetch-verified citations, 90.6% peer-reviewed or government sources

Online care, from intake to delivery

GHK-Cu care, made simple

Choose your plan, complete a private medical intake, and connect with a licensed provider. If prescribed, treatment ships discreetly to your door.

GHK-Cu care catalog product image
Compounded injectable treatmentPrepared after approval
Catalog image. Dispensed product and packaging may vary by pharmacy.

Your care plan includes

Everything you need to get started

From$143.10per month
Licensed providerMedical reviewIf prescribedTreatment includedAt no added costDiscreet shippingWhen you need itOrder support
Choose your planChange or cancel future refills anytime
Due today$161.10then monthly

Encrypted checkout provider review required shipping included

  1. 01
    Choose your planSelect the supply and refill preference that works for you.
  2. 02
    Complete your intakeShare your health history in our private, secure flow.
  3. 03
    Provider reviewIf appropriate, your prescription is prepared and shipped.

Prescription treatment requires an online medical evaluation. A provider will determine whether treatment is medically appropriate; approval is not guaranteed.

Key facts

  • StatusCompounded, not FDA-approved
  • Skin permeability coefficient2.43 +/- 0.51 x 10^-4 cm/h (dermatomed human skin, in vitro, 48 h infinite dose)source
  • Copper permeated, 48 h136.2 +/- 17.5 ug/cm2, with 82 to 97 ug/cm2 retained as depotsource
  • Intact skin, 9 hAlmost no peptide or copper permeated without microneedlessource
  • With microneedle pretreatment134 nmol peptide, 705 nmol copper permeated in 9 hsource
  • Plasma GHK, healthy older adults133.0 +/- 54.54 ng/mL (n=11, 2023)source
  • Plasma GHK, COPD70.27 +/- 38.87 ng/mL (n=9, P = 0.009 vs controls)source
  • Reported age declineAbout 200 ng/mL at 20 to about 80 ng/mL at 60, per the originating lineagesource
  • ClassCopper-binding tripeptide (glycyl-L-histidyl-L-lysine); matrikine candidateChemical referencesource
  • Molecular identityGHK 340.38 Da (CID 73587); 1:1 Cu complex 401.91 Da (CID 165429100)Chemical referencesource
  • INCI label nameCopper tripeptide-1 (cosmetics)Regulatory recordsource
  • Status: cosmetic serumsCosmetics only; no FDA approval exists or is required for cosmeticsRegulatory recordsource
  • Status: compounded non-injectable503A interim Category 1 (under evaluation); restored May 5, 2026; PCAC before end of Feb 2027Regulatory recordsource
  • Status: injectable vialsResearch-only; on FDA's compounding safety-risks page; zero human trialsRegulatory recordsource
  • Approved drugs containing GHK-Cu0 (Drugs@FDA query returns no matches)Regulatory recordsource
  • Registered trials3 on ClinicalTrials.gov; none injectable; 1 topical phase 2 recruitingRegulatory recordsource
  • RCT-tagged GHK-Cu records1 (2006 laser study; objective endpoints null)Absence of evidencesource
  • Endogenous plasma GHK133.0 ng/mL healthy older adults; 70.27 ng/mL COPD (2023 measurement)Human observationalsource
  • CIR cosmetic safetySafe as used; surveyed concentrations typically under 10 ppmExpert panelsource

Read the full GHK-Cu monograph

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Everything on GHK-Cu and copper peptides, organized the way you research it.

All guides

214 in-depth, individually cited guides.

Comparisons 63 guides

Evidence 62 guides

Sourcing 45 guides

Safety 28 guides

Dosing 16 guides

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